Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR2B | P41595 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HTR1B | P28222 | 10/20 | 0.48 |
| ▸ | HTR1D | P28221 | 9/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847568 | 0.84 | HTR1A (0.74) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL2791148 | 0.81 | HTR1A (0.74) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL189975 | 0.81 | HTR1A (0.58) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL1957 | 0.81 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL29396422 | 0.81 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL3273179 | 0.81 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL13081207 | 0.81 | LMNA (0.66) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL1437 | 0.80 | HTR1A (0.98) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL27833198 | 0.80 | HTR1A (0.72) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL2166 | 0.80 | HTR1A (0.98) | HTR1AHTR2AHTR2BLMNAADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400986-A1 | ENHANCED MIGRAINE TREATMENTS BASED ON GHRELIN MIMETICS | Helsinn Therapeutics (U.S.), Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099522-A1 | ENHANCED MIGRAINE TREATMENTS BASED ON GHRELIN MIMETICS | HELSINN THERAPEUTICS (U.S.), INC. (US) | 2010-09-02 | — | — | WO | disclosed |