Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 10/20 | 0.41 |
| ▸ | HTR1D | P28221 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189974 | 0.81 | HTR1A (0.68) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL14543690 | 0.79 | HTR1D (0.55) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL1847568 | 0.78 | HTR1A (0.74) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL3755821 | 0.76 | LMNA (0.46) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Oxalic Acid SCHEMBL2788592 | 0.74 | HTR1A (0.67) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL2881897 | 0.74 | LMNA (0.47) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL2791148 | 0.74 | HTR1A (0.74) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL3273179 | 0.73 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL29396422 | 0.73 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL1957 | 0.73 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400986-A1 | ENHANCED MIGRAINE TREATMENTS BASED ON GHRELIN MIMETICS | Helsinn Therapeutics (U.S.), Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099522-A1 | ENHANCED MIGRAINE TREATMENTS BASED ON GHRELIN MIMETICS | HELSINN THERAPEUTICS (U.S.), INC. (US) | 2010-09-02 | — | — | WO | disclosed |