Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.38 |
| ▸ | MMP2 | P08253 | 5/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003249 | 0.84 | EGFR (0.42) | NOTUMMAPTTSHRHTTNPC1 | |
| SCHEMBL19003343 | 0.79 | MAPT (0.46) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL18985528 | 0.79 | NQO2 (0.56) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL19003466 | 0.79 | NQO2 (0.56) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL19003299 | 0.77 | MAPT (0.52) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL19003302 | 0.77 | HSD17B1 (0.48) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL19003306 | 0.76 | TRPV1 (0.61) | HSD17B1HSD17B2NOTUMMAPTKDM4E | |
| SCHEMBL19003303 | 0.76 | MAOB (0.52) | HSD17B1HSD17B2MAPTALDH1A1HTT | |
| SCHEMBL18985199 | 0.75 | NAMPT (0.48) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL19003304 | 0.74 | ABL1 (0.58) | MAPTKDM4EALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |