Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18985267 | 0.85 | MAPT (0.41) | MAPTTAS2R14KMT2AMEN1LMNA | |
| SCHEMBL19003278 | 0.82 | KMT2A (0.42) | MAPTKMT2AMEN1LMNAPSMD14 | |
| SCHEMBL19003340 | 0.81 | TP53 (0.52) | MAPTAPPKMT2AMEN1LMNA | |
| SCHEMBL19003300 | 0.79 | HSD17B1 (0.45) | MAPTKMT2AMEN1LMNAKDM4E | |
| SCHEMBL19003339 | 0.77 | MAPT (0.57) | MAPTAPPKMT2AMEN1LMNA | |
| SCHEMBL19003344 | 0.74 | KMT2A (0.49) | MAPTAPPKMT2AMEN1LMNA | |
| SCHEMBL19003306 | 0.72 | TRPV1 (0.61) | MAPTKMT2AMEN1KDM4ENOTUM | |
| SCHEMBL15859149 | 0.72 | MAPT (0.74) | MAPTAPPKMT2AMEN1LMNA | |
| SCHEMBL15859151 | 0.72 | MAPT (0.74) | MAPTAPPKMT2AMEN1LMNA | |
| SCHEMBL14730414 | 0.72 | MAPT (0.74) | MAPTAPPKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |