SCHEMBL19003249

SCHEMBL19003249

O=C(/C=C/c1ccc(Br)s1)Nc1ccc(-c2nnco2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.42
MAPT P10636 3/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
NPC1 O15118 1/20 0.40
LMNA P02545 1/20 0.40
HTT P42858 1/20 0.40
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
CDK19 Q9BWU1 1/20 0.38
ESR1 P03372 1/20 0.38
POLB P06746 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19003300 0.84 HSD17B1 (0.45) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL18985267 0.78 MAPT (0.41) MAPTKMT2AMEN1NPC1LMNA
SCHEMBL19003250 0.76 MAPT (0.51) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003244 0.75 MAOB (0.51) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003248 0.73 LMNA (0.56) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003257 0.73 KDM4E (0.49) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003253 0.72 MAOB (0.56) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003264 0.72 NR4A1 (0.56) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003274 0.72 MMP1 (0.58) EGFRMAPTKMT2AMEN1NPC1
SCHEMBL19003349 0.72 RXFP1 (0.48) EGFRMAPTKMT2AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO disclosed