Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.65 |
| ▸ | LMNA | P02545 | 8/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | HTT | P42858 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 6/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003239 | 0.79 | MAPT (0.81) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL3484458 | 0.79 | MAPT (0.77) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL3484460 | 0.79 | MAPT (0.77) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL19003455 | 0.79 | MAPT (0.77) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL19003467 | 0.79 | PORCN (0.54) | MEN1KMT2ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL19003457 | 0.77 | MAPT (0.72) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL19003234 | 0.72 | MAPT (0.69) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL10363643 | 0.71 | CYP3A4 (0.53) | MAPTLMNAKMT2AHTTNPC1 | |
| SCHEMBL17509589 | 0.70 | KMT2A (0.57) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL31457418 | 0.70 | KMT2A (0.57) | MAPTLMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |