Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20586088 | 0.79 | ALDH1A1 (0.50) | NPC1KDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18992133 | 0.79 | ALDH1A1 (0.50) | NPC1KDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5479636 | 0.76 | CES2 (0.60) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL6218406 | 0.74 | ALDH1A1 (0.52) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL4840325 | 0.74 | ALDH1A1 (0.52) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL4840329 | 0.74 | ALDH1A1 (0.52) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL28533131 | 0.74 | CES2 (0.56) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9333827 | 0.74 | ALDH1A1 (0.49) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL11756323 | 0.74 | ALDH1A1 (0.53) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL28533102 | 0.73 | SMN1; SMN2 (0.55) | NPC1PKMRAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210164005-A1 | METHODS FOR INDUCING BIOORTHOGONAL REACTIVITY | UNIVERSITY OF DELAWARE (US) | 2021-06-03 | — | — | US | disclosed |
| US-10875840-B2 | Methods for inducing bioorthogonal reactivity | UNIVERSITY OF DELAWARE (US) | 2020-12-29 | — | — | US | disclosed |
| WO-2017106427-A1 | METHODS FOR INDUCING BIOORTHOGONAL REACTIVITY | FOX JOSEPH (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10875840-B2 | Methods for inducing bioorthogonal reactivity | CBR1, CBR3, DUOX1 | NPC1 4645/4885PKM 2526/4885RAB9A 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.