Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147158 | 0.82 | IGF1R (0.59) | IGF1RPOLBALDH1A1MAPTLMNA | |
| SCHEMBL5572065 | 0.80 | KCNH2 (0.69) | POLBHTR1AKCNH2 | |
| SCHEMBL4491439 | 0.79 | IGF1R (0.56) | IGF1RPOLBALDH1A1MAPTLMNA | |
| SCHEMBL19003598 | 0.79 | IGF1R (0.56) | IGF1RPOLBALDH1A1MAPTLMNA | |
| SCHEMBL30874651 | 0.79 | IGF1R (0.64) | IGF1RPOLBALDH1A1MAPTLMNA | |
| SCHEMBL4486168 | 0.79 | IGF1R (0.56) | IGF1RPOLBALDH1A1MAPTLMNA | |
| SCHEMBL27715352 | 0.78 | KCNH2 (0.74) | POLBHTR1AKCNH2 | |
| SCHEMBL10053231 | 0.77 | KCNH2 (0.64) | POLBALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL3867807 | 0.77 | KDM4E (0.64) | POLBALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL5243910 | 0.76 | KDM4E (0.52) | POLBALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |