Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905214 | 0.90 | SIGMAR1 (0.47) | SIGMAR1CA1CA2LMNACA12 | |
| SCHEMBL28816385 | 0.85 | SIGMAR1 (0.59) | SIGMAR1CA2GNAI3GNAO1GNAI1 | |
| SCHEMBL4559648 | 0.85 | SIGMAR1 (0.43) | SIGMAR1OPRD1CHRM5CHRM3 | |
| SCHEMBL10413132 | 0.85 | SIGMAR1 (0.43) | SIGMAR1GNAI3GNAO1GNAI1EP300 | |
| SCHEMBL2875257 | 0.83 | SIGMAR1 (0.47) | SIGMAR1CA1CA2MEN1KMT2A | |
| SCHEMBL6032886 | 0.82 | SIGMAR1 (0.41) | SIGMAR1GNAI3GNAO1GNAI1MEN1 | |
| Hydrochloric Acid SCHEMBL9697226 | 0.81 | MAPT (0.49) | SIGMAR1CA1CA2MEN1KMT2A | |
| SCHEMBL2764645 | 0.81 | SIGMAR1 (0.38) | SIGMAR1CA1CA2CA12CA9 | |
| SCHEMBL28706411 | 0.81 | LMNA (0.45) | SIGMAR1CA1CA2GNAI3GNAO1 | |
| SCHEMBL28716337 | 0.81 | LMNA (0.45) | SIGMAR1CA1CA2LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42376-E1 | Substituted 3-cyanoquinolines | WYETH HOLDINGS CORPORATION (US) | 2011-05-17 | — | — | US | disclosed |
| EP-1861376-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F. Hoffmann-Roche AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097261-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-21 | — | — | WO | disclosed |