Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.45 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395095 | 0.98 | SIGMAR1 (0.65) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL10687011 | 0.95 | SIGMAR1 (0.65) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7862964 | 0.92 | SIGMAR1 (0.61) | SIGMAR1CHRM5CHRM3ALDH1A1GNAI3 | |
| SCHEMBL1905216 | 0.90 | SIGMAR1 (0.71) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6897984 | 0.88 | ALDH1A1 (0.57) | SIGMAR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28391170 | 0.85 | SIGMAR1 (0.64) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6897980 | 0.83 | SIGMAR1 (0.63) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL2875261 | 0.83 | ALDH1A1 (0.72) | SIGMAR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4711520 | 0.82 | SIGMAR1 (0.65) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL13032706 | 0.81 | ALDH1A1 (0.50) | SIGMAR1ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58201774-A | — | — | None | — | — | JP | disclosed |
| EP-3008055-B1 | TETRAZOLONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | disclosed |
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-20160083357-A1 | NOVEL TETRAZOLONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-03-24 | — | — | US | disclosed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | disclosed |
| US-RE42376-E1 | Substituted 3-cyanoquinolines | WYETH HOLDINGS CORPORATION (US) | 2011-05-17 | — | — | US | disclosed |
| JP-S58201774-A | 1-AMINOCARBONYLMETHYL-SUBSTITUTED PIPERAZINE DERIVATIVE | HOKURIKU SEIYAKU CO LTD | 1983-11-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083357-A1 | NOVEL TETRAZOLONE DERIVATIVES | TBXA2R, CYP11B2, NR1I2 | SIGMAR1 118/4885CHRM5 1255/4885CHRM3 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.