Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18531743 | 0.91 | ALDH1A1 (0.65) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL6897984 | 0.91 | ALDH1A1 (0.57) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL10223654 | 0.87 | ALDH1A1 (0.74) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL13864818 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TDP1SIGMAR1KDM4ETSHR | |
| SCHEMBL13032706 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL22600490 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL19606960 | 0.84 | ALDH1A1 (0.75) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL13864732 | 0.83 | ALDH1A1 (0.55) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL1900359 | 0.83 | SIGMAR1 (0.67) | ALDH1A1TDP1SIGMAR1SMN1; SMN2HTT | |
| SCHEMBL7445738 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TDP1SIGMAR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317697-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100179109-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-07-15 | — | — | US | disclosed |
| US-20100130471-A1 | Renin Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-05-27 | — | — | US | disclosed |
| EP-2167609-A1 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009096996-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-06 | — | — | WO | disclosed |
| WO-2008124575-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179109-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ALDH1A1 1625/4885TDP1 1161/4885SIGMAR1 2374/4885 |
| US-20100317697-A1 | Renin Inhibitors | REN, ACE, SERPINB1 | ALDH1A1 1056/4885TDP1 1008/4885SIGMAR1 2925/4885 |
| US-20100130471-A1 | Renin Inhibitors | ACE, REN, DNPEP | ALDH1A1 2221/4885TDP1 946/4885SIGMAR1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.