Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12535863 | 0.85 | IGF1R (0.56) | MAPTIGF1RMEN1KMT2AABCB1 | |
| SCHEMBL13875129 | 0.84 | MEN1 (0.62) | MAPTIGF1RMEN1KMT2AABCB1 | |
| SCHEMBL13648740 | 0.83 | ALDH1A1 (0.66) | MAPTIGF1RMEN1KMT2AKDM4E | |
| SCHEMBL18975478 | 0.80 | MAPT (0.63) | MAPTKDM4EMAPK1L3MBTL1POLB | |
| SCHEMBL7903765 | 0.79 | MAPT (0.67) | MAPTSMN1; SMN2KDM4ETP53ALDH1A1 | |
| SCHEMBL5915112 | 0.76 | DRD2 (0.68) | MAPTKDM4EALDH1A1GFERLMNA | |
| SCHEMBL14440421 | 0.75 | GAA (0.62) | MAPTALDH1A1GFERLMNATDP1 | |
| SCHEMBL12781852 | 0.74 | ADRA2A (0.71) | MAPTIGF1RMEN1KMT2AABCB1 | |
| SCHEMBL15702599 | 0.74 | HTR1A (0.63) | MAPTIGF1RMEN1KMT2AABCB1 | |
| SCHEMBL11570592 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |