SCHEMBL19003773

SCHEMBL19003773

N#Cc1ccc(-c2ccc3c4c(ccc(-c5ccc(C(F)(F)F)cc5)c24)-c2c-3c(-c3ccccc3)c3ccccc3c2-c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 3/20 0.53
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
PTGDR2 Q9Y5Y4 1/20 0.43
PTPN5 P54829 1/20 0.39
CYP3A4 P08684 1/20 0.37
CYP3A5 P20815 1/20 0.37
ATM Q13315 1/20 0.37
ENPP1 P22413 1/20 0.36
KDM1A O60341 4/20 0.36
PDK2 Q15119 1/20 0.36
CYP11B2 P19099 1/20 0.36
BACE1 P56817 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19003768 0.89 ATM (0.42) ALDH1A1PTGDR2ATMCYP11B2
SCHEMBL19003781 0.89 KIF11 (0.53) KIF11ALDH1A1MAPTSMN1; SMN2TDP1
SCHEMBL13932230 0.82 KIF11 (0.52) KIF11ALDH1A1MAPTSMN1; SMN2TDP1
SCHEMBL13932229 0.82 KIF11 (0.52) KIF11ALDH1A1MAPTSMN1; SMN2TDP1
SCHEMBL19003779 0.82 ADORA2A (0.41) ALDH1A1MAPTPTGDR2CYP3A4ATM
SCHEMBL14073020 0.81 ALDH1A1 (0.37) ALDH1A1MAPTPTGDR2ATM
SCHEMBL4070688 0.80 KIF11 (0.49) KIF11ALDH1A1MAPTSMN1; SMN2TDP1
SCHEMBL4073469 0.80 ATM (0.40) ALDH1A1ATMENPP1PDK2
SCHEMBL13170658 0.80 ATM (0.40) ALDH1A1ATMENPP1PDK2
SCHEMBL13932278 0.79 KIF11 (0.45) KIF11ALDH1A1MAPTSMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017104767-A1 COMPOUND FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME TDK株式会社 2017-06-22 WO disclosed