Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900502 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TSHRSOAT1LTA4HALOX5 | |
| SCHEMBL13279978 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL15899122 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TSHRSOAT1LTA4HCHRM3 | |
| SCHEMBL11019198 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL28289730 | 0.78 | ALDH1A1 (0.45) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL7689385 | 0.77 | ALDH1A1 (0.47) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL712647 | 0.76 | ALDH1A1 (0.49) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL27274916 | 0.76 | L3MBTL1 (0.48) | ALDH1A1TSHRSOAT1TDP1L3MBTL1 | |
| SCHEMBL9110590 | 0.76 | TSHR (0.41) | ALDH1A1TSHRSOAT1LTA4HTDP1 | |
| SCHEMBL30959761 | 0.74 | TSHR (0.47) | ALDH1A1TSHRLTA4HNAAATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499145-B1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | UNIV MICHIGAN (US) | 2016-01-27 | — | — | EP | disclosed |
| US-9079913-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140378680-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-25 | — | — | US | disclosed |
| US-8877796-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130296303-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| US-8518984-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2499145-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | The Regents Of The University Of Michigan (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011060049-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-19 | — | — | WO | disclosed |
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378680-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | ALDH1A1 1498/4885TSHR 2230/4885SOAT1 4262/4885 |
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | ALDH1A1 1498/4885TSHR 2230/4885SOAT1 4262/4885 |
| US-20130296303-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | ALDH1A1 1498/4885TSHR 2230/4885SOAT1 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.