SCHEMBL7689385

SCHEMBL7689385

CC12COC(CCOCc3ccccc3)(OC1)OC2

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
TSHR P16473 1/20 0.42
SOAT1 P35610 1/20 0.38
CHRM3 P20309 5/20 0.37
CHRM2 P08172 2/20 0.37
CHRM1 P11229 2/20 0.37
SLC6A2 P23975 1/20 0.37
PDE4A P27815 1/20 0.37
SLC6A4 P31645 1/20 0.37
OPRM1 P35372 1/20 0.37
SLC6A3 Q01959 1/20 0.37
TACR1 P25103 1/20 0.37
LTA4H P09960 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NAAA Q02083 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26328667 0.84 TACR1 (0.45) ALDH1A1TSHRTACR1TAAR1
SCHEMBL13279978 0.82 ALDH1A1 (0.50) ALDH1A1TSHRSOAT1CHRM3CHRM2
SCHEMBL712647 0.78 ALDH1A1 (0.49) ALDH1A1TSHRSOAT1CHRM3CHRM2
SCHEMBL1900505 0.77 ALDH1A1 (0.46) ALDH1A1TSHRSOAT1CHRM3CHRM2
SCHEMBL1900502 0.77 ALDH1A1 (0.46) ALDH1A1TSHRSOAT1CHRM3CHRM2
SCHEMBL11019198 0.76 ALDH1A1 (0.44) ALDH1A1TSHRSOAT1LTA4HTDP1
SCHEMBL4750397 0.76 TSHR (0.47) ALDH1A1TSHRCHRM3CHRM2CHRM1
SCHEMBL30959761 0.76 TSHR (0.47) ALDH1A1TSHRCHRM3CHRM2CHRM1
SCHEMBL27274916 0.74 L3MBTL1 (0.48) ALDH1A1TSHRSOAT1TDP1L3MBTL1
SCHEMBL15899122 0.74 ALDH1A1 (0.43) ALDH1A1TSHRSOAT1CHRM3CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6337334-B1 SUBSTITUTED BIPYRIMIDINES WITH ETHERS AND SULFONAMIDE GROUPS COMPOUNDS EXHIBIT STRONG BINDING INHIBITORY ACTIVITY AGAINST ENDOTHELIN HAVING POTENT VASOCONSTRICTIVE EFFECT AND CELL PROLIFERATION EFFECT. KOWA CO., LTD. (JP) 2002-01-08 US disclosed
US-6008224-A POTENT ENDOTHELIN ANTAGONISM TREATING VASOCONSTRICTIVE EFFECT AND CELL PROLIFERATION EFFECT KOWA CO., LTD. (JP) 1999-12-28 US disclosed
EP-0801062-A1 PYRIMIDINE DERIVATIVES KOWA CO. LTD. (JP) 1997-10-15 EP disclosed