Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19005658 | 0.82 | ADRA1A (0.33) | ADRA1A | |
| SCHEMBL19005734 | 0.72 | CHRNB4 (0.35) | — | |
| SCHEMBL19005732 | 0.71 | CHRNB2 (0.33) | ADRA1A | |
| SCHEMBL13755325 | 0.68 | — | — | |
| SCHEMBL28866941 | 0.68 | — | — | |
| SCHEMBL26251503 | 0.66 | HRH3 (0.42) | SIGMAR1HRH3 | |
| SCHEMBL26780072 | 0.64 | ADRA1A (0.35) | ADRA1A | |
| SCHEMBL26251536 | 0.62 | HSD11B1 (0.41) | ADRA1AHRH3 | |
| SCHEMBL27660997 | 0.62 | — | — | |
| SCHEMBL29248096 | 0.61 | ADRA1A (0.36) | ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |