SCHEMBL855313

SCHEMBL855313

NCc1cc(Cl)nc(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 6/20 0.54
LOX P28300 1/20 0.54
LOXL3 P58215 1/20 0.54
PNMT P11086 1/20 0.41
HSP90AB1 P08238 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35
S1PR2 O95136 1/20 0.34
CSNK2A1 P68400 2/20 0.33
KMT2A Q03164 2/20 0.33
RECQL P46063 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ROCK1 Q13464 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL25243547 0.97 LOXL2 (0.52) LOXL2LOXLOXL3PNMTHSP90AB1
SCHEMBL12291537 0.85 LOXL2 (0.47) LOXL2LOXLOXL3PNMTHSP90AB1
SCHEMBL16635420 0.84 LOXL2 (0.45) LOXL2LOXLOXL3PNMTHSP90AB1
SCHEMBL29714427 0.84 LOX (0.45) LOXL2LOXLOXL3PNMTHSP90AB1
SCHEMBL19755849 0.84 LOX (0.45) LOXL2LOXLOXL3PNMTHSP90AB1
SCHEMBL18050015 0.79 LOXL2 (0.50) LOXL2LOXLOXL3HSP90AB1KDM4E
SCHEMBL190086 0.77 RECQL (0.41) LOXL2LOXLOXL3HSP90AB1S1PR2
SCHEMBL16635330 0.74 LOXL2 (0.38) LOXL2LOXLOXL3
Hydrochloric Acid SCHEMBL6869464 0.74 RECQL (0.39) LOXL2LOXLOXL3HSP90AB1S1PR2
SCHEMBL904515 0.72 RECQL (0.54) LOXL2LOXLOXL3HSP90AB1S1PR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250059185-A1 BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2025-02-20 US disclosed
EP-4448522-A1 BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2024-10-23 EP disclosed
WO-2023110958-A1 BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2023-06-22 WO disclosed
US-11236046-B2 Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators GENENTECH, INC. (US) 2022-02-01 US disclosed
EP-3313837-B1 CARBOLINE ANTIPARASITICS ZOETIS SERVICES LLC (US) 2020-09-09 EP disclosed
US-10570129-B2 Carboline antiparasitics ZOETIS SERVICES LLC (US) 2020-02-25 US disclosed
US-20200048197-A1 SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS GENENTECH, INC. (US) 2020-02-13 US disclosed
US-20200031822-A1 CARBOLINE ANTIPARASITICS ZOETIS SERVICES LLC (US) 2020-01-30 US disclosed
EP-3256463-B1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2019-10-09 EP disclosed
EP-3256463-B1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2019-10-09 EP disclosed
WO-2008092942-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2008-08-07 WO disclosed
US-20080070902-A1 Cinnamide Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-03-20 US disclosed
EP-1757591-A1 CINNAMIDE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-02-28 EP disclosed
WO-2006004062-A1 2,6-DICHLORO-4-PYRIDYLMETHYLAMINE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL DISEASE CONTROL AGENT KUREHA CORPORATION (JP) 2006-01-12 WO disclosed
US-20060004013-A1 Alzheimer's disease, senile dementia, Down syndrome or amyloidosis; 3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; imidazolyl-functional compounds inhibit production of Amyloid beta 40 and Amyloid beta 42; low hygroscopicity; good solubility EISAI CO., LTD. 2006-01-05 US disclosed
US-20050049285-A1 Dichloropyridyl methyl cyanamidines BAYER CROPSCIENCE AG (DE) 2005-03-03 US disclosed
EP-1345494-A2 DICHLOROPYRIDYL METHYLAMIDES Bayer CropScience AG (DE) 2003-09-24 EP disclosed
EP-1345904-A1 DICHLOROPYRIDYL METHYL CYANAMIDINES Bayer CropScience AG (DE) 2003-09-24 EP disclosed
WO-2002050037-A1 DICHLOROPYRIDYL METHYL CYANAMIDINES BAYER CROPSCIENCE AG (DE) 2002-06-27 WO disclosed
WO-2002050035-A2 INSECTICIDAL AND FUNGICIDAL (2,6-DICHLORO-4-PYRIDYL) METHYLCARBAMATES USED AS PLANT PROTECTIVE AGENTS BAYER CROPSCIENCE AG (DE) 2002-06-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059185-A1 BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS MGLL, LIPC, PNLIP LOXL2 182/4885LOX 625/4885LOXL3 295/4885
US-20200048197-A1 SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS TRPA1, TRPV1, TRPV2 LOXL2 2972/4885LOX 3601/4885LOXL3 3098/4885
US-20080070902-A1 Cinnamide Compound C1S, CCR1, CNR1 LOXL2 2773/4885LOX 3705/4885LOXL3 2457/4885
US-10570129-B2 Carboline antiparasitics ADRA1D, DRD1, CHRM1 LOXL2 2959/4885LOX 4048/4885LOXL3 1979/4885
US-11236046-B2 Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators TRPA1, TRPV1, TRPV2 LOXL2 2972/4885LOX 3601/4885LOXL3 3098/4885
US-20200031822-A1 CARBOLINE ANTIPARASITICS DRD1, ADRA1D, DRD2 LOXL2 3401/4885LOX 4239/4885LOXL3 2504/4885
US-20050049285-A1 Dichloropyridyl methyl cyanamidines MRPL21, DDT, FBL LOXL2 1670/4885LOX 3461/4885LOXL3 2191/4885
US-20060004013-A1 Alzheimer's disease, senile dementia, Down syndrome or amyloidosis; 3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; imidazolyl-functional compounds inhibit production of Amyloid beta 40 and Amyloid beta 42; low hygroscopicity; good solubility PSEN1, APP, BACE1 LOXL2 4523/4885LOX 4279/4885LOXL3 4696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.