Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | NCF1 | P14598 | 3/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056940 | 0.85 | MEN1 (0.51) | HTTMEN1KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL1238925 | 0.80 | CYP1A2 (0.60) | HTTMEN1KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL13230471 | 0.79 | NR3C1 (0.46) | NR4A2MEN1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL13437973 | 0.79 | LATS1 (0.51) | NR4A2 | |
| SCHEMBL6602282 | 0.79 | NQO2 (0.61) | NR4A2MEN1KMT2AL3MBTL1NCF1 | |
| SCHEMBL12763789 | 0.79 | TLR7 (0.66) | HTTMEN1KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL10266503 | 0.79 | NR4A2 (0.48) | NR4A2L3MBTL1CYP2C19 | |
| SCHEMBL6609095 | 0.79 | NR4A2 (0.48) | NR4A2HTTMEN1KMT2AL3MBTL1 | |
| SCHEMBL6789826 | 0.79 | CYP1A2 (0.58) | HTTMEN1KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL4903031 | 0.79 | NQO2 (0.59) | HTTMEN1KMT2AL3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
| US-20170174639-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174639-A1 | EIS INHIBITORS | ABCC1, ATP5ME, ABCG2 | NR4A2 4159/4885HTT 4803/4885MEN1 3949/4885 |
| US-20180162867-A1 | EIS INHIBITORS | EP300, ACAT1, ACAT2 | NR4A2 4074/4885HTT 4813/4885MEN1 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.