Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RXRA | P19793 | 2/20 | 0.61 |
| ▸ | RXRB | P28702 | 2/20 | 0.61 |
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
| ▸ | RARB | P10826 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10243658 | 0.88 | ALDH1A1 (0.87) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL403155 | 0.88 | ALDH1A1 (0.87) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL1330795 | 0.86 | ALDH1A1 (1.00) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL19901 | 0.86 | ALDH1A1 (1.00) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL1330335 | 0.86 | ALDH1A1 (1.00) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL19010906 | 0.85 | RAB9A (0.54) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL19010919 | 0.85 | RAB9A (0.65) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL6913296 | 0.84 | ALDH1A1 (0.95) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL6909050 | 0.84 | ALDH1A1 (0.95) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL2590166 | 0.84 | ALDH1A1 (0.95) | ALDH1A1RAB9ASMN1; SMN2NPC1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180135121-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
| US-9890426-B2 | Pore-forming protein conjugate compositions and methods | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170175183-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170175183-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | TIAL1, NUP93, PORCN | ALDH1A1 4877/4885RAB9A 525/4885SMN1; SMN2 4764/4885 |
| US-20180135121-A1 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS | TIAL1, NUP93, PORCN | ALDH1A1 4876/4885RAB9A 540/4885SMN1; SMN2 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.