Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18990479 | 0.85 | KDM4E (0.45) | ALDH1A1USP2SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18990046 | 0.83 | MTHFD2 (0.42) | MAOAMAOBALDH1A1MTHFD2SMN1; SMN2 | |
| SCHEMBL18989779 | 0.83 | USP2 (0.41) | ALDH1A1MTHFD2USP2SMN1; SMN2NPSR1 | |
| SCHEMBL18989760 | 0.80 | LOXL2 (0.45) | ALDH1A1MTHFD2SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18989572 | 0.79 | TNF (0.44) | ALDH1A1MTHFD2SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18989887 | 0.77 | TSHR (0.50) | ALDH1A1MTHFD2USP2SMN1; SMN2NPSR1 | |
| SCHEMBL19013524 | 0.76 | MAPT (0.44) | MAOAMAOBALDH1A1MTHFD2SMN1; SMN2 | |
| SCHEMBL18989792 | 0.76 | ALDH1A1 (0.49) | ALDH1A1USP2SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18990054 | 0.76 | LMNA (0.49) | ALDH1A1MTHFD2USP2SMN1; SMN2NPSR1 | |
| SCHEMBL18990374 | 0.76 | POLB (0.46) | ALDH1A1MTHFD2SMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |