Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.42 |
| ▸ | RHEB | Q15382 | 7/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189726 | 0.77 | DAO (0.49) | DAORHEBFLT3PCSK9HRH4 | |
| SCHEMBL4979042 | 0.77 | DAO (0.51) | DAORHEBFLT3PCSK9HRH4 | |
| SCHEMBL19013674 | 0.75 | DAO (0.50) | DAORHEBFLT3PCSK9HRH4 | |
| SCHEMBL5917425 | 0.74 | DAO (0.49) | DAORHEBFLT3PCSK9HRH4 | |
| SCHEMBL4561870 | 0.74 | RHEB (0.57) | DAORHEBFLT3HRH4 | |
| SCHEMBL6448492 | 0.71 | RHEB (0.56) | DAORHEBFLT3HRH4NOS1 | |
| SCHEMBL4561367 | 0.71 | RHEB (0.36) | DAORHEBFLT3PCSK9HRH4 | |
| SCHEMBL1439650 | 0.69 | DAO (0.51) | DAORHEBFLT3HRH4 | |
| SCHEMBL30468720 | 0.69 | DAO (0.51) | DAORHEBFLT3HRH4 | |
| SCHEMBL152992 | 0.68 | MTNR1A (0.47) | DAOFLT3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |