Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20682406 | 0.80 | HRH3 (0.42) | JAK2JAK1F2R | |
| SCHEMBL20382066 | 0.77 | HSD11B1 (0.43) | JAK2JAK1F2RHSD11B1SMN1; SMN2 | |
| SCHEMBL19014176 | 0.73 | SPR (0.36) | JAK2JAK1GAAHSD11B1SMN1; SMN2 | |
| SCHEMBL25910650 | 0.73 | HRH3 (0.38) | JAK2JAK1 | |
| SCHEMBL20154480 | 0.72 | ALDH1A1 (0.38) | HSD11B1SMN1; SMN2CHRM1L3MBTL1 | |
| SCHEMBL20682398 | 0.72 | DPP4 (0.33) | JAK2JAK1HSD11B1SMN1; SMN2 | |
| SCHEMBL5035936 | 0.72 | GAA (0.59) | GAASMN1; SMN2CHRM1THRBATM | |
| SCHEMBL10035079 | 0.70 | HRH3 (0.43) | HSD11B1SMN1; SMN2 | |
| SCHEMBL13045920 | 0.70 | EPHX2 (0.47) | — | |
| SCHEMBL21723067 | 0.69 | SMN1; SMN2 (0.38) | HSD11B1SMN1; SMN2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |