Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901492 | 1.00 | MCHR1 (0.41) | MCHR1PTGDR2KCNH2KIF11ADRB3 | |
| SCHEMBL1902209 | 0.93 | CYP1A2 (0.45) | MCHR1PTGDR2 | |
| SCHEMBL1902210 | 0.93 | CYP1A2 (0.45) | MCHR1PTGDR2 | |
| SCHEMBL1904022 | 0.89 | PTGDR2 (0.48) | MCHR1PTGDR2 | |
| SCHEMBL1904021 | 0.89 | PTGDR2 (0.48) | MCHR1PTGDR2 | |
| SCHEMBL1900071 | 0.88 | RAB9A (0.44) | PTGDR2 | |
| SCHEMBL2492234 | 0.88 | RAB9A (0.44) | PTGDR2 | |
| SCHEMBL1902531 | 0.87 | HPGD (0.43) | PTGDR2 | |
| SCHEMBL2491209 | 0.87 | HPGD (0.43) | PTGDR2 | |
| SCHEMBL1902893 | 0.87 | MEN1 (0.43) | MCHR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |