Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ATF4 | P18848 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902210 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL1901492 | 0.93 | MCHR1 (0.41) | PTGDR2MCHR1 | |
| SCHEMBL1901494 | 0.93 | MCHR1 (0.41) | PTGDR2MCHR1 | |
| SCHEMBL1902531 | 0.89 | HPGD (0.43) | CYP1A2SMN1; SMN2LMNATP53PTGDR2 | |
| SCHEMBL2491209 | 0.89 | HPGD (0.43) | CYP1A2SMN1; SMN2LMNATP53PTGDR2 | |
| SCHEMBL2490412 | 0.88 | SIGMAR1 (0.39) | CYP1A2PTGDR2MAPTMTNR1AMTNR1B | |
| SCHEMBL1904906 | 0.88 | SIGMAR1 (0.39) | CYP1A2PTGDR2MAPTMTNR1AMTNR1B | |
| SCHEMBL1907674 | 0.87 | PTGDR2 (0.48) | CYP1A2CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL1900071 | 0.87 | RAB9A (0.44) | CYP1A2SMN1; SMN2LMNAPTGDR2MAPT | |
| SCHEMBL2492234 | 0.87 | RAB9A (0.44) | CYP1A2SMN1; SMN2LMNAPTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |