Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | GALR2 | O43603 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22737771 | 0.79 | KMT2A (0.57) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22737355 | 0.75 | MAPT (0.57) | MAPTLMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8239323 | 0.75 | MAPT (0.51) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11812589 | 0.74 | LMNA (0.94) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14146747 | 0.74 | BRAF (0.62) | MAPTSMN1; SMN2TDP1CA12CA1 | |
| SCHEMBL29345084 | 0.74 | MAPT (0.95) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22737561 | 0.74 | GBA1 (0.49) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL25722605 | 0.73 | SMN1; SMN2 (0.65) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1443608 | 0.72 | ALDH1A1 (0.55) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29345120 | 0.72 | POLB (0.58) | MAPTLMNACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106367-A1 | METHOD OF TREATING NEURODEGENERATIVE DISORDERS BY RESCUING ALPHA-SYNUCLEIN TOXICITY | D.E. SHAW RESEARCH, LLC (US) | 2017-06-22 | — | — | WO | disclosed |