Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12569511 | 0.95 | DDB1 (0.54) | DDB1CRBNHSD17B10ALOX5ADRA1B | |
| SCHEMBL30858424 | 0.89 | DDB1 (0.64) | DDB1CRBNALOX5ADRA1BADRA1D | |
| SCHEMBL31058279 | 0.86 | HSD17B10 (0.50) | DDB1CRBNHSD17B10ALOX5ADRA1B | |
| SCHEMBL4809461 | 0.86 | MEN1 (0.57) | HSD17B10ALOX5ADRA1BADRA1DADRA1A | |
| SCHEMBL24388818 | 0.83 | HSD17B10 (0.50) | HSD17B10ALOX5ADRA1BADRA1DADRA1A | |
| SCHEMBL85903 | 0.80 | ALOX5 (0.55) | HSD17B10ALOX5ADRA1BMEN1KMT2A | |
| SCHEMBL5480318 | 0.80 | ADRB1 (0.57) | DDB1CRBNALOX5MEN1KMT2A | |
| SCHEMBL7787664 | 0.79 | HSD17B10 (0.53) | HSD17B10MEN1KMT2AHPGDTSHR | |
| SCHEMBL22430467 | 0.79 | MEN1 (0.56) | HSD17B10MEN1KMT2ALMNAHPGD | |
| SCHEMBL2760313 | 0.79 | HSD17B10 (0.57) | HSD17B10MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791273-B2 | 4R,5S-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity | JSC GRINDEKS (LV) | 2014-07-29 | — | — | US | claimed |
| EP-2496555-B1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | GRINDEKS JSC (LV) | 2013-08-28 | — | — | EP | claimed |
| EP-2496555-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | Grindeks, A Joint Stock Company (LV) | 2012-09-12 | — | — | EP | claimed |
| US-20120215010-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | JSC GRINDEKS (LV) | 2012-08-23 | — | — | US | claimed |
| WO-2011054888-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2011-05-12 | — | — | WO | claimed |
| WO-2024175450-A1 | SUBSTITUTED S-ALANINATE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2024-08-29 | — | — | WO | disclosed |
| EP-3072892-B1 | PYRIDINE DERIVATIVE AND MEDICAL USE THEREOF | CHENGDU EASTON BIOPHARMACEUTICALS CO LTD (CN) | 2019-10-23 | — | — | EP | disclosed |
| CN-110049983-A | Medical compounds | 细胞中心有限公司 | 2019-07-23 | — | — | CN | disclosed |
| US-20140296317-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | JSC GRINDEKS (LV) | 2014-10-02 | — | — | US | disclosed |
| US-20140296317-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | JSC GRINDEKS (LV) | 2014-10-02 | — | — | US | disclosed |
| US-8791273-B2 | 4R,5S-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity | JSC GRINDEKS (LV) | 2014-07-29 | — | — | US | disclosed |
| US-8791273-B2 | 4R,5S-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity | JSC GRINDEKS (LV) | 2014-07-29 | — | — | US | disclosed |
| WO-2011054888-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011054888-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2011-05-12 | — | — | WO | disclosed |
| US-7592456-B2 | Arylsulfonylnaphthalene derivatives as 5HT2A antagonists | MERCK SHARP & DOHME LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-20070281952-A1 | Arylsulfonylnaphthalene Derivatives As 5Ht2a Antagonists | MERCK SHARPE & DOHME LIMITED (GB) | 2007-12-06 | — | — | US | disclosed |
| US-4427439-A | Composition for plant growth regulation | GAF CORPORATION (US) | 1984-01-24 | — | — | US | disclosed |
| US-4361436-A | Composition for plant growth regulation | GAF CORPORATION (US) | 1982-11-30 | — | — | US | disclosed |
| US-4359334-A | N-HETEROCYCLIC AMIDE AND A 2-HALOETHYLSULFINATE | GAF CORPORATION (US) | 1982-11-16 | — | — | US | disclosed |
| US-4328026-A | PLANT GROWTH REGULATORS, ETHYLENE GENERATORS | GAF CORPORATION (US) | 1982-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296317-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | NAAA, NAT1, NAA15 | DDB1 3909/4885CRBN 4188/4885HSD17B10 1636/4885 |
| US-20070281952-A1 | Arylsulfonylnaphthalene Derivatives As 5Ht2a Antagonists | HTR2A, HTR2C, HTR1A | DDB1 3700/4885CRBN 2504/4885HSD17B10 1348/4885 |
| US-20120215010-A1 | 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY | NAAA, NAT1, NAA15 | DDB1 3909/4885CRBN 4188/4885HSD17B10 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.