Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.80 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.61 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | EIF4E | P06730 | 1/20 | 0.59 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.54 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.54 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901897 | 1.00 | DUSP3 (0.80) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1901898 | 1.00 | DUSP3 (0.80) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL17527731 | 0.92 | DUSP3 (0.76) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1905191 | 0.89 | DUSP3 (0.81) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1905192 | 0.89 | DUSP3 (0.81) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1905190 | 0.89 | DUSP3 (0.81) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1907678 | 0.89 | DUSP3 (1.00) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1907681 | 0.89 | DUSP3 (1.00) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL1907680 | 0.89 | DUSP3 (1.00) | DUSP3MAP3K5HIF1ANMAPTMEN1 | |
| SCHEMBL3903272 | 0.86 | HIF1AN (0.80) | MAP3K5HIF1ANMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176859-A1 | High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK) | NORTH CAROLINA CENTRAL UNIVERSITY | 2016-06-23 | — | — | US | disclosed |
| US-20160176859-A1 | High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK) | NORTH CAROLINA CENTRAL UNIVERSITY | 2016-06-23 | — | — | US | disclosed |
| US-20160176859-A1 | High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK) | NORTH CAROLINA CENTRAL UNIVERSITY | 2016-06-23 | — | — | US | disclosed |
| WO-2016025023-A1 | A HIGH-THROUGHPUT ASSAY FOR IDENTIFYING SMALL MOLECULES THAT MODULATE AMP-ACTIVATED PROTEIN KINASE (AMPK) | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2016025023-A1 | A HIGH-THROUGHPUT ASSAY FOR IDENTIFYING SMALL MOLECULES THAT MODULATE AMP-ACTIVATED PROTEIN KINASE (AMPK) | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2016-02-18 | — | — | WO | disclosed |
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176859-A1 | High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK) | PRKAA1, PRKAG2, PRKAA2 | DUSP3 431/4885MAP3K5 46/4885HIF1AN 806/4885 |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | DUSP3 2075/4885MAP3K5 2663/4885HIF1AN 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.