Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5466633 | 0.93 | LMNA (0.44) | LMNACYP1A2CYP2C19CYP2D6HDAC1 | |
| SCHEMBL23929244 | 0.91 | THRB (0.43) | LMNAHDAC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL23929266 | 0.83 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4 | |
| SCHEMBL30464709 | 0.83 | HDAC8 (0.43) | HDAC1HDAC3HDAC2SMN1; SMN2ALDH1A1 | |
| SCHEMBL27635962 | 0.83 | HDAC8 (0.43) | HDAC1HDAC3HDAC2SMN1; SMN2ALDH1A1 | |
| SCHEMBL20655979 | 0.83 | HDAC8 (0.43) | HDAC1HDAC3HDAC2SMN1; SMN2ALDH1A1 | |
| SCHEMBL29745004 | 0.83 | HDAC8 (0.43) | HDAC1HDAC3HDAC2SMN1; SMN2ALDH1A1 | |
| SCHEMBL11533028 | 0.83 | HDAC8 (0.43) | HDAC1HDAC3HDAC2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28770186 | 0.81 | KCNH3 (0.41) | LMNAHDAC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL20746963 | 0.81 | ALDH1A1 (0.47) | LMNACYP1A2CYP2C19CYP2D6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174639-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174639-A1 | EIS INHIBITORS | ABCC1, ATP5ME, ABCG2 | LMNA 2571/4885CYP1A2 2393/4885CYP2C19 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.