Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | IDO1 | P14902 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19018960 | 0.85 | POLB (0.64) | POLBPKMMEN1KMT2ATAS2R14 | |
| SCHEMBL22425031 | 0.82 | POLB (0.84) | POLBIDO1PKMMEN1KMT2A | |
| SCHEMBL19019156 | 0.82 | MAPT (0.67) | POLBPKMMEN1KMT2ATAS2R14 | |
| SCHEMBL24876169 | 0.77 | MEN1 (0.72) | POLBPKMMEN1KMT2AMAPT | |
| SCHEMBL9535518 | 0.77 | NPSR1 (0.65) | POLBIDO1PKMMEN1KMT2A | |
| SCHEMBL26597984 | 0.77 | KMT2A (0.74) | POLBPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1279534 | 0.74 | TAS2R14 (1.00) | POLBPKMMEN1KMT2ATAS2R14 | |
| SCHEMBL24430215 | 0.74 | POLB (0.71) | POLBIDO1PKMMEN1KMT2A | |
| SCHEMBL31680036 | 0.74 | THRB (0.58) | POLBPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL18173883 | 0.73 | MAPT (0.79) | POLBPKMMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208000-B2 | Eis inhibitors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170174639-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174639-A1 | EIS INHIBITORS | ABCC1, ATP5ME, ABCG2 | POLB 1092/4885IDO1 2014/4885PKM 624/4885 |
| US-10208000-B2 | Eis inhibitors | ABCC1, ATP5ME, ABCG2 | POLB 1092/4885IDO1 2014/4885PKM 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.