Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19020268 | 0.82 | ALDH1A1 (0.42) | ESR1DYRK1BMKNK1MKNK2ALDH1A1 | |
| SCHEMBL19020319 | 0.78 | BRD4 (0.35) | ESR1DYRK1BMKNK1MKNK2ALDH1A1 | |
| SCHEMBL19020430 | 0.75 | OPRK1 (0.36) | ESR1DYRK1B | |
| SCHEMBL19020440 | 0.74 | KDM1A (0.35) | MEN1KMT2AEHMT2 | |
| SCHEMBL7498201 | 0.68 | LMNA (0.49) | ESR1ALDH1A1ALDH2ALDH3A1MEN1 | |
| SCHEMBL16823787 | 0.68 | BRD4 (0.39) | ESR1DYRK1BLMNAMAPT | |
| SCHEMBL19020269 | 0.67 | ALDH1A1 (0.45) | ALDH1A1IDO1LMNAEHMT2 | |
| SCHEMBL19019621 | 0.64 | VRK1 (0.32) | ALDH1A1IDO1KDM4EHPGD | |
| SCHEMBL19020428 | 0.64 | PTGDR2 (0.40) | ALDH1A1 | |
| SCHEMBL23473126 | 0.62 | LMNA (0.33) | ALDH1A1ALDH2ALDH3A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103670-A1 | 1H-IMIDAZO[4,5-B]PYRIDINYL AND 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDINYL HETEROCYCLIC BET BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LID. (CA) | 2017-06-22 | — | — | WO | disclosed |