Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | LIPE | Q05469 | 5/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 4/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15383840 | 0.84 | KDM4E (0.44) | KDM4EMEN1KMT2ARAB9ACA1 | |
| SCHEMBL14746564 | 0.83 | LPL (0.53) | KDM4EMEN1KMT2ACA1CA2 | |
| SCHEMBL14746622 | 0.83 | LIPE (0.46) | CA1CA2CA9DGAT1LIPE | |
| SCHEMBL15989442 | 0.83 | CA1 (0.49) | MEN1KMT2ACA1CA2CA9 | |
| SCHEMBL16023927 | 0.82 | PTGS1 (0.41) | KDM4EMEN1KMT2APOLBRAB9A | |
| SCHEMBL31491396 | 0.81 | DGAT1 (0.47) | KDM4EPOLBCA1CA2CA9 | |
| SCHEMBL14165741 | 0.81 | LPL (0.53) | KDM4EMEN1KMT2ACA1CA2 | |
| SCHEMBL805967 | 0.80 | LIPE (0.60) | RAB9ALIPE | |
| SCHEMBL30297686 | 0.80 | DGAT1 (0.52) | CA1CA2CA9ALDH1A1DGAT1 | |
| SCHEMBL5784394 | 0.80 | DGAT1 (0.52) | CA1CA2CA9ALDH1A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655502-A | Acid addition salts of Trk inhibiting compounds | 小野药品工业株式会社 | 2020-01-07 | — | — | CN | disclosed |
| US-10399959-B2 | Acid-addition salt of Trk-inhibiting compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-09-03 | — | — | US | disclosed |
| EP-3184519-B1 | ACID-ADDITION SALT OF TRK-INHIBITING COMPOUND | ONO PHARMACEUTICAL CO (JP) | 2019-04-24 | — | — | EP | disclosed |
| US-20170240527-A1 | ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-08-24 | — | — | US | disclosed |
| EP-3184519-A1 | ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND | ONO Pharmaceutical Co., Ltd. (JP) | 2017-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240527-A1 | ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND | NTRK1, NGF, NTRK2 | KDM4E 4148/4885MEN1 1774/4885KMT2A 3744/4885 |
| US-10399959-B2 | Acid-addition salt of Trk-inhibiting compound | NTRK1, NGF, NTRK2 | KDM4E 4148/4885MEN1 1774/4885KMT2A 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.