Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPIB | P23284 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | FURIN | P09958 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432234 | 0.89 | MASP2 (0.42) | MASP2PPIBTLR2F10CPB1 | |
| SCHEMBL1431623 | 0.88 | MASP2 (0.41) | MASP2PPIBTLR2F10CPB1 | |
| SCHEMBL1432321 | 0.85 | MASP2 (0.38) | MASP2PPIBTLR2SMN1; SMN2F10 | |
| SCHEMBL1432038 | 0.84 | MASP2 (0.38) | MASP2PPIBTLR2F10NAMPT | |
| SCHEMBL1906629 | 0.84 | HPGD (0.39) | MASP2HPGDALDH1A1F2PRSS1 | |
| SCHEMBL1433593 | 0.82 | MASP2 (0.35) | MASP2PPIBNAMPTFURIN | |
| SCHEMBL1901133 | 0.82 | MASP2 (0.39) | MASP2PPIBALDH1A1F10CPB1 | |
| SCHEMBL1432698 | 0.81 | DPP4 (0.38) | MASP2CPB1CPB2 | |
| SCHEMBL1432135 | 0.81 | MASP2 (0.39) | MASP2PPIBALDH1A1F10CPB1 | |
| SCHEMBL1907759 | 0.80 | PSMB10 (0.41) | MASP2TLR2ALDH1A1CPB2FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |