Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | MASP2 | O00187 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901133 | 0.85 | MASP2 (0.39) | F2PRSS1MASP2LMNAHDAC1 | |
| SCHEMBL1901982 | 0.84 | MASP2 (0.39) | HPGDF2PRSS1MASP2ALDH1A1 | |
| SCHEMBL1432135 | 0.82 | MASP2 (0.39) | F2PRSS1MASP2LMNAALDH1A1 | |
| SCHEMBL1906624 | 0.82 | F2 (0.40) | F2PRSS1MASP2EPHX2 | |
| SCHEMBL1906627 | 0.82 | F2 (0.40) | F2PRSS1MASP2EPHX2 | |
| SCHEMBL1432234 | 0.82 | MASP2 (0.42) | F2PRSS1MASP2 | |
| SCHEMBL1431623 | 0.80 | MASP2 (0.41) | F2PRSS1MASP2HDAC1 | |
| SCHEMBL1432038 | 0.79 | MASP2 (0.38) | MASP2HDAC1 | |
| SCHEMBL1433593 | 0.79 | MASP2 (0.35) | MASP2 | |
| SCHEMBL1432321 | 0.78 | MASP2 (0.38) | F2PRSS1MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |