Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957327 | 0.83 | SIGMAR1 (0.42) | SIGMAR1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19022009 | 0.82 | SIGMAR1 (0.36) | SIGMAR1KDM4EKMT2AMEN1DPP4 | |
| SCHEMBL27410749 | 0.80 | KDM4E (0.40) | SIGMAR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL27410751 | 0.80 | KDM4E (0.40) | SIGMAR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL19010252 | 0.80 | KDM4E (0.40) | SIGMAR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL23866609 | 0.79 | KDM4E (0.42) | SIGMAR1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19000029 | 0.79 | KDM4E (0.42) | SIGMAR1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL23866597 | 0.79 | KDM4E (0.42) | SIGMAR1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6678936 | 0.77 | SIGMAR1 (0.58) | SIGMAR1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29902875 | 0.77 | HTT (0.53) | KDM4EKMT2ASMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106607-A1 | POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |