Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19000029 | 1.00 | KDM4E (0.42) | KDM4EPABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL23866597 | 1.00 | KDM4E (0.42) | KDM4EPABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL19010252 | 0.83 | KDM4E (0.40) | KDM4ESIGMAR1ATMMEN1KMT2A | |
| SCHEMBL27410749 | 0.83 | KDM4E (0.40) | KDM4ESIGMAR1ATMMEN1KMT2A | |
| SCHEMBL27410751 | 0.83 | KDM4E (0.40) | KDM4ESIGMAR1ATMMEN1KMT2A | |
| SCHEMBL21676255 | 0.82 | CASP6 (0.42) | KDM4ESIGMAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23835774 | 0.82 | ATM (0.50) | KDM4EPABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL19000013 | 0.81 | PABPC1 (0.36) | KDM4EPABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL2553398 | 0.81 | SIGMAR1 (0.40) | KDM4EPABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL19022016 | 0.79 | SIGMAR1 (0.43) | KDM4ESIGMAR1ATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | KDM4E 1906/4885PABPC1 3076/4885APOBEC3A 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.