Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030689 | 0.74 | IRAK4 (0.49) | IRAK4 | |
| SCHEMBL28655169 | 0.70 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL19030052 | 0.69 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL28668587 | 0.66 | IRAK4 (0.58) | IRAK4 | |
| SCHEMBL28356925 | 0.61 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL22265286 | 0.59 | ALDH1A1 (0.36) | IRAK4 | |
| SCHEMBL14960622 | 0.59 | ERCC1 (0.46) | — | |
| SCHEMBL19030262 | 0.58 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL12320460 | 0.58 | LPO (0.40) | — | |
| SCHEMBL308400 | 0.56 | LPO (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3394066-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |