Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532617 | 0.79 | ALDH1A1 (0.40) | ALDH1A1THRBMAPTPOLBKDM4E | |
| SCHEMBL15075715 | 0.79 | EPHX2 (0.35) | — | |
| SCHEMBL4532619 | 0.79 | ALDH1A1 (0.41) | ALDH1A1THRBMAPTPOLBKDM4E | |
| SCHEMBL4518207 | 0.78 | TSHR (0.38) | ALDH1A1THRBMAPTPOLBKDM4E | |
| SCHEMBL10587862 | 0.74 | ALDH1A1 (0.38) | ALDH1A1THRBMAPTPOLBKDM4E | |
| SCHEMBL20161623 | 0.66 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL20161758 | 0.66 | ALDH1A1 (0.38) | ALDH1A1THRBMAPTPOLBKDM4E | |
| SCHEMBL20561158 | 0.61 | ALDH1A1 (0.62) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL21711061 | 0.61 | PER2 (0.49) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL19036508 | 0.59 | KDM4E (0.40) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |