Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.55 |
| ▸ | AR | P10275 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861548 | 0.83 | PGR (0.55) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL19042656 | 0.83 | NR3C1 (0.68) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8541353 | 0.80 | PGR (0.53) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL19042724 | 0.80 | NR3C1 (0.83) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8538261 | 0.80 | PGR (0.53) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8541351 | 0.80 | PGR (0.53) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8541045 | 0.80 | PGR (0.59) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8427053 | 0.78 | PGR (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL23653624 | 0.77 | PGR (0.75) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8424832 | 0.77 | PGR (0.79) | PGRNR3C1ARCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017112909-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2017-06-29 | — | — | WO | disclosed |