Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | NQO1 | P15559 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24136195 | 0.85 | L3MBTL1 (0.61) | L3MBTL1LMNAALDH1A1KDM4EFFAR1 | |
| SCHEMBL8277617 | 0.85 | L3MBTL1 (0.68) | L3MBTL1LMNAMMP2ALDH1A1NPC1 | |
| SCHEMBL1807043 | 0.84 | L3MBTL1 (0.72) | L3MBTL1LMNAMMP2ALDH1A1NPC1 | |
| SCHEMBL1806524 | 0.84 | L3MBTL1 (1.00) | L3MBTL1LMNAMMP2ALDH1A1NPC1 | |
| SCHEMBL20382734 | 0.84 | NQO1 (0.56) | L3MBTL1LMNAALDH1A1NPC1NQO1 | |
| SCHEMBL22434873 | 0.82 | L3MBTL1 (0.59) | L3MBTL1LMNAALDH1A1NPC1KDM4E | |
| SCHEMBL11949155 | 0.82 | L3MBTL1 (0.76) | L3MBTL1LMNAMMP2ALDH1A1FFAR1 | |
| SCHEMBL2468006 | 0.82 | L3MBTL1 (0.69) | L3MBTL1LMNAMMP2FFAR1 | |
| SCHEMBL25193934 | 0.81 | MAOB (0.73) | LMNAALDH1A1NPC1KDM4EHTT | |
| SCHEMBL38674 | 0.81 | L3MBTL1 (0.68) | L3MBTL1LMNAMMP2ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |