Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4058823 | 0.81 | KDM4E (0.58) | KDM4EMAPK1HIF1ACHRM5CHRM1 | |
| SCHEMBL5157716 | 0.80 | MAPK1 (0.55) | KDM4EMAPK1HIF1AADRA1ASMN1; SMN2 | |
| SCHEMBL8763339 | 0.78 | KDM4E (0.61) | KDM4EMAPK1HIF1ACHRM5CHRM1 | |
| SCHEMBL5155263 | 0.78 | MEN1 (0.56) | KDM4EMAPK1HIF1AADRA1ASMN1; SMN2 | |
| SCHEMBL19309079 | 0.78 | MEN1 (0.56) | KDM4EMAPK1HIF1AADRA1ASMN1; SMN2 | |
| SCHEMBL22199596 | 0.77 | MAPK1 (0.48) | KDM4EMAPK1HIF1AACHEADRA1A | |
| SCHEMBL22849678 | 0.77 | SMN1; SMN2 (0.49) | KDM4EMAPK1HIF1AACHESMN1; SMN2 | |
| SCHEMBL19192288 | 0.77 | KDM4E (0.65) | KDM4EMAPK1HIF1AACHEADRA1A | |
| SCHEMBL21788052 | 0.76 | ADRA1A (0.58) | KDM4EMAPK1HIF1AADRA1ASMN1; SMN2 | |
| SCHEMBL24508760 | 0.76 | CES2 (0.52) | KDM4EMAPK1HIF1AACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322137-A1 | Stable hydroalcoholic compositions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-1374847-A1 | Stable hydroalcoholic compositions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 2004-01-02 | — | — | EP | disclosed |