Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 11/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28320699 | 0.77 | LMNA (0.42) | KDM4EALDH1A1MAPT | |
| SCHEMBL151936 | 0.76 | IMPDH2 (0.64) | ARIMPDH2IMPDH1KDM4EALDH1A1 | |
| SCHEMBL29489135 | 0.76 | IMPDH2 (0.64) | ARIMPDH2IMPDH1KDM4EALDH1A1 | |
| SCHEMBL13667404 | 0.74 | SIGMAR1 (0.35) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL11193357 | 0.73 | IMPDH2 (0.61) | ARIMPDH2IMPDH1KDM4EALDH1A1 | |
| SCHEMBL27527094 | 0.73 | AR (0.37) | AR | |
| SCHEMBL1971208 | 0.73 | IMPDH2 (0.44) | ARIMPDH2IMPDH1KDM4EALDH1A1 | |
| SCHEMBL3205617 | 0.73 | ALDH1A1 (0.52) | ARIMPDH2IMPDH1KDM4EALDH1A1 | |
| SCHEMBL17052813 | 0.72 | CYP1A2 (0.52) | KDM4EALDH1A1MAPT | |
| SCHEMBL5788213 | 0.71 | IMPDH2 (0.43) | ARIMPDH2IMPDH1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734671-B | Benzimidazole derivative, preparation method and application thereof | 北京医药集团有限责任公司 | 2021-03-09 | — | — | CN | claimed |
| CN-109734671-A | Benzimidazoles derivative, preparation method and application | 北京医药集团有限责任公司 | 2019-05-10 | — | — | CN | claimed |
| CN-109734671-B | Benzimidazole derivative, preparation method and application thereof | 北京医药集团有限责任公司 | 2021-03-09 | — | — | CN | disclosed |
| US-10336710-B2 | Benzimidazole derivatives, preparation method therefor, and applications thereof | BEIJING PHARMACEUTICAL GROUP CO LTD (CN) | 2019-07-02 | — | — | US | disclosed |
| CN-109734671-A | Benzimidazoles derivative, preparation method and application | 北京医药集团有限责任公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-105601571-B | Benzimidazole derivative, preparation method and application thereof | 北京医药集团有限责任公司 | 2019-03-05 | — | — | CN | disclosed |
| US-20180297959-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | BEIJING PHARMACEUTICAL GROUP CO LTD (CN) | 2018-10-18 | — | — | US | disclosed |
| WO-2017107864-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | 北京医药集团有限责任公司 | 2017-06-29 | — | — | WO | disclosed |
| CN-105601571-A | Benzimidazole derivative, preparation method and application thereof | CHINA RESOURCES SAIKE PHARMACEUTICAL CO LTD | 2016-05-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336710-B2 | Benzimidazole derivatives, preparation method therefor, and applications thereof | WEE1, CYP51A1, WEE2 | AR 3740/4885IMPDH2 163/4885IMPDH1 79/4885 |
| US-20180297959-A1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | WEE1, CYP51A1, WEE2 | AR 3740/4885IMPDH2 163/4885IMPDH1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.