Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023911 | 1.00 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1KDM4EALOX15 | |
| SCHEMBL15628607 | 0.89 | ALDH1A1 (0.38) | ALDH1A1MAPTL3MBTL1KDM4EALOX15 | |
| SCHEMBL15628457 | 0.87 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1KDM4EALOX15 | |
| SCHEMBL15628603 | 0.85 | ADRB1 (0.48) | ALDH1A1KDM4ELMNA | |
| SCHEMBL15628460 | 0.85 | LGMN (0.42) | ALDH1A1MAPTL3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL15628450 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1MAPTMAPK1SMN1; SMN2HTT | |
| SCHEMBL15628442 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4ERORC | |
| SCHEMBL12330921 | 0.81 | HIF1A (0.44) | ALDH1A1MAPTL3MBTL1KDM4EALOX15 | |
| SCHEMBL15628549 | 0.80 | DPP4 (0.35) | — | |
| SCHEMBL15628606 | 0.80 | DPP4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934238-B1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2017-06-28 | — | — | EP | disclosed |