Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 7/20 | 0.77 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 5/20 | 0.49 |
| ▸ | RXRB | P28702 | 2/20 | 0.49 |
| ▸ | RXRG | P48443 | 2/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26835770 | 0.88 | HCAR3 (0.59) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL4547078 | 0.85 | HCAR3 (0.56) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL13611416 | 0.84 | HCAR3 (0.76) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| Hydrochloric Acid SCHEMBL27869687 | 0.83 | HCAR3 (0.73) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL31737249 | 0.82 | HCAR3 (0.66) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL11565561 | 0.82 | HCAR3 (0.66) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL185127 | 0.82 | HCAR3 (0.65) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL11565320 | 0.81 | HCAR3 (0.64) | HCAR3P4HA1P4HTMMAPTRXRA | |
| SCHEMBL24422211 | 0.80 | HCAR3 (0.71) | HCAR3P4HA1P4HTMMAPTHCAR2 | |
| SCHEMBL8595311 | 0.79 | HCAR3 (0.61) | HCAR3P4HA1P4HTMMAPTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9243000-B2 | Thia-triaza-indacenes | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| US-8653097-B2 | Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (P13-kinases) inhibitor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| US-8304556-B2 | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-8288379-B2 | Thia-triaza-cyclopentazulenes | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20120108618-A1 | THIA-TRIAZA-INDACENES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110312940-A1 | TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (P13-KINASES) INHIBITOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-22 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110112087-A1 | Thia-triaza-cyclopentazulenes | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-12 | — | — | US | disclosed |
| US-7935825-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2011-05-03 | — | — | US | disclosed |
| EP-1436264-B1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | ALLERGAN INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20070219255-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | BURK ROBERT M | 2007-09-20 | — | — | US | disclosed |
| US-7214678-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20060217349-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2006-09-28 | — | — | US | disclosed |
| US-7098223-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050032746-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2005-02-10 | — | — | US | disclosed |
| US-6825221-B2 | PROSTAGLANDIN INHIBITORS FOR TREATING RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS, POST-OPERATIVE PAIN, PAIN ASSOCIATED WITH DENTAL | ALLERGAN, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1436264-A1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | Allergan, Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030078236-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2003-04-24 | — | — | US | disclosed |
| WO-2003033470-A1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | ALLERGAN, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312940-A1 | TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (P13-KINASES) INHIBITOR | CCNK, CDK1, CDKN1A | HCAR3 2651/4885P4HA1 1222/4885P4HTM 1437/4885 |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | HCAR3 2774/4885P4HA1 260/4885P4HTM 727/4885 |
| US-20110112087-A1 | Thia-triaza-cyclopentazulenes | CCNA1, MKI67, CCNT1 | HCAR3 3378/4885P4HA1 37/4885P4HTM 337/4885 |
| US-20070219255-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | HCAR3 195/4885P4HA1 412/4885P4HTM 1460/4885 |
| US-20120108618-A1 | THIA-TRIAZA-INDACENES | CCNA1, MKI67, CCNT1 | HCAR3 4031/4885P4HA1 185/4885P4HTM 1056/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | HCAR3 2774/4885P4HA1 260/4885P4HTM 727/4885 |
| US-20050032746-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | HCAR3 195/4885P4HA1 412/4885P4HTM 1460/4885 |
| US-20030078236-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRD1, OPRK1, OPRL1 | HCAR3 462/4885P4HA1 718/4885P4HTM 3033/4885 |
| US-20060217349-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | HCAR3 195/4885P4HA1 412/4885P4HTM 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.