SCHEMBL19066431

SCHEMBL19066431

CC(C)Oc1cc(-c2nc(CNC(=O)c3c(O)cccc3O)co2)ccc1OC(F)F

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LCLAT1 Q6UWP7 3/20 0.35
GAA P10253 1/20 0.34
TSHR P16473 1/20 0.34
KMT2A Q03164 1/20 0.34
KLKB1 P03952 2/20 0.34
PDE4D Q08499 3/20 0.33
ADORA2A P29274 2/20 0.33
PDE4A P27815 2/20 0.33
PDE4B Q07343 2/20 0.33
PDE4C Q08493 2/20 0.33
PPARA Q07869 2/20 0.32
WDR5 P61964 1/20 0.32
PPARG P37231 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
S1PR5 Q9H228 1/20 0.32
EZH2 Q15910 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24297149 0.94 KMT2A (0.35) LCLAT1GAATSHRKMT2AADORA2A
SCHEMBL19066416 0.93 KCNA5 (0.36) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL19066440 0.91 LCLAT1 (0.37) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL31239126 0.91 LCLAT1 (0.37) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL19066434 0.90 LCLAT1 (0.38) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL19066439 0.87 KCNA5 (0.38) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL29204624 0.87 KMT2A (0.36) LCLAT1GAATSHRKMT2AKLKB1
SCHEMBL29204580 0.86 MAPT (0.39) LCLAT1TSHRKMT2APDE4DADORA2A
SCHEMBL19066415 0.86 ADRB1 (0.33) LCLAT1GAAKMT2AKLKB1
SCHEMBL19066419 0.86 NAAA (0.34) LCLAT1GAATSHRKMT2AKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240366573-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-11-07 US disclosed
US-20220117944-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2022-04-21 US disclosed
US-20220117944-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2022-04-21 US disclosed
US-20200171006-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-06-04 US disclosed
US-20200171006-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-06-04 US disclosed
US-10588893-B2 Ointment containing an oxazole compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-03-17 US disclosed
US-10588893-B2 Ointment containing an oxazole compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2020-03-17 US disclosed
US-20190000810-A1 OINTMENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2019-01-03 US disclosed
US-20190000810-A1 OINTMENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2019-01-03 US disclosed
EP-3397619-A1 OINTMENT Otsuka Pharmaceutical Co., Ltd. (JP) 2018-11-07 EP disclosed
WO-2017115780-A1 OINTMENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-07-06 WO disclosed
WO-2017115780-A1 OINTMENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240366573-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND PDE12, PDE4B, PDE4A LCLAT1 1886/4885GAA 1316/4885TSHR 4579/4885
US-20200171006-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND PDE12, PDE4B, PDE4A LCLAT1 1886/4885GAA 1316/4885TSHR 4579/4885
US-20220117944-A1 OINTMENT CONTAINING AN OXAZOLE COMPOUND PDE12, PDE4B, PDE4A LCLAT1 1886/4885GAA 1316/4885TSHR 4579/4885
US-10588893-B2 Ointment containing an oxazole compound PDE12, PDE4B, PDE4A LCLAT1 1886/4885GAA 1316/4885TSHR 4579/4885
US-20190000810-A1 OINTMENT PDE12, PDE4B, PDE4A LCLAT1 1574/4885GAA 808/4885TSHR 4648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.