Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 4/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3171879 | 0.80 | MGLL (0.62) | TSHRMGLLHSP90AA1CCR6ALDH1A1 | |
| SCHEMBL5078820 | 0.75 | MGLL (0.62) | MGLLHSP90AA1CCR6ALDH1A1FAAH | |
| SCHEMBL11757226 | 0.70 | TSHR (0.42) | TSHRMGLLBCL2A1CHRM2CHRM4 | |
| SCHEMBL10268369 | 0.68 | ALDH1A1 (0.50) | TSHRBCL2A1CHRM2CHRM4ADRB1 | |
| Dimethachlon SCHEMBL410360 | 0.68 | TSHR (0.50) | TSHRBCL2A1CHRM2CHRM4ADRB1 | |
| SCHEMBL11756755 | 0.67 | TSHR (0.44) | TSHRMGLLBCL2A1CHRM2CHRM4 | |
| SCHEMBL1899173 | 0.67 | CA1 (0.53) | — | |
| SCHEMBL10833708 | 0.66 | MEN1 (0.39) | TSHRMGLLBCL2A1CHRM2CHRM4 | |
| SCHEMBL17338891 | 0.66 | TSHR (0.43) | TSHRHSP90AA1CCR6BCL2A1ALDH1A1 | |
| SCHEMBL11762036 | 0.65 | TSHR (0.47) | TSHRBCL2A1ALDH1A1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10072017-B2 | Compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2018-09-11 | — | — | US | disclosed |
| US-20170204110-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC | 2017-07-20 | — | — | US | disclosed |
| US-20170204110-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC | 2017-07-20 | — | — | US | disclosed |
| WO-2017117239-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC (US) | 2017-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204110-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SERPINB1, ELANE | TSHR 4320/4885MGLL 2407/4885HSP90AA1 1473/4885 |
| US-10072017-B2 | Compounds and methods for the treatment of cystic fibrosis | CFTR, SERPINB1, ELANE | TSHR 4320/4885MGLL 2407/4885HSP90AA1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.