Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092562 | 0.76 | DPP4 (0.49) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL7795327 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL8250998 | 0.75 | SLC6A3 (0.45) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| Acetic Acid SCHEMBL11731347 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL7452089 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL12126153 | 0.73 | ALOX15 (0.55) | SMN1; SMN2NPC1RAB9ATDP1NPSR1 | |
| SCHEMBL27389996 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL856450 | 0.72 | GABRA5 (0.61) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL12158564 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ATDP1POLB | |
| SCHEMBL19072060 | 0.71 | RAB9A (0.39) | SMN1; SMN2NPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257160-B1 | DIAMIDE INHIBITORS OF CYTOCHROME P450 | SEQUOIA PHARMACEUTICALS INC (US) | 2017-07-05 | — | — | EP | disclosed |