Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.40 |
| ▸ | USP1 | O94782 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079769 | 0.62 | PDE4D (0.68) | LMNARAB9A | |
| SCHEMBL27591071 | 0.62 | L3MBTL1 (0.44) | HSD11B1LMNAHPGDRAB9A | |
| SCHEMBL11404811 | 0.59 | L3MBTL1 (0.41) | LMNASIGMAR1 | |
| SCHEMBL11341092 | 0.59 | L3MBTL1 (0.41) | LMNASIGMAR1 | |
| SCHEMBL27609548 | 0.59 | TDP1 (0.47) | LMNAHPGDRAB9A | |
| SCHEMBL14605809 | 0.58 | HSD11B1 (1.00) | HSD11B1 | |
| Methylamine SCHEMBL27590925 | 0.57 | TDP1 (0.44) | LMNAHPGDRAB9A | |
| SCHEMBL27590827 | 0.57 | KMT2A (0.47) | LMNAHPGDRAB9A | |
| SCHEMBL10070201 | 0.56 | L3MBTL1 (0.60) | LMNASIGMAR1RAB9A | |
| SCHEMBL2515036 | 0.56 | TSHR (0.56) | LMNASIGMAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | HSD11B1 1310/4885USP1 862/4885LMNA 3846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.