Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28491401 | 1.00 | CA2 (0.56) | CA2CA1MAPK1ZDHHC7GAA | |
| SCHEMBL28497772 | 1.00 | CA2 (0.56) | CA2CA1MAPK1ZDHHC7GAA | |
| SCHEMBL585232 | 1.00 | CA2 (0.56) | CA2CA1MAPK1ZDHHC7GAA | |
| SCHEMBL1725609 | 1.00 | CA2 (0.56) | CA2CA1MAPK1ZDHHC7GAA | |
| Hydrochloric Acid SCHEMBL27586576 | 0.98 | CA2 (0.55) | CA2CA1MAPK1ZDHHC7GAA | |
| Hydrochloric Acid SCHEMBL27649377 | 0.98 | CA2 (0.55) | CA2CA1MAPK1ZDHHC7GAA | |
| Hydrochloric Acid SCHEMBL27649378 | 0.98 | CA2 (0.55) | CA2CA1MAPK1ZDHHC7GAA | |
| Ethane SCHEMBL28789613 | 0.98 | CA2 (0.55) | CA2CA1MAPK1ZDHHC7GAA | |
| SCHEMBL3836421 | 0.98 | CA2 (0.58) | CA2CA1MAPK1ZDHHC7GAA | |
| Oxalic Acid SCHEMBL28618643 | 0.95 | CA2 (0.51) | CA2CA1MAPK1ZDHHC7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117720550-A | Synthesis method of (S) -3-methyl-4-oxo-2-oxa-8-azaspiro [4.5] decane-8-carboxylic acid tert-butyl ester | 深圳市华先医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-113423711-B | Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof | 建新公司 | 2024-03-15 | — | — | CN | claimed |
| CN-117586257-A | Compound containing 2, 8-diazaspiro [4.5] decan-1-one skeleton and application thereof | 中国药科大学 | 2024-02-23 | — | — | CN | claimed |
| CN-116348463-A | Spiro derivatives of alpha-D-galactopyranoside | 爱杜西亚药品有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-113121537-B | Synthesis method of 2, 8-diazaspiro [4.5] decane-8-tert-butyl formate | 南通药明康德医药科技有限公司 | 2022-11-08 | — | — | CN | claimed |
| CN-109661396-B | Spiro-fused cyclic ureas as ROCK inhibitors | 百时美施贵宝公司 | 2022-07-01 | — | — | CN | claimed |
| CN-113135921-A | Dihydropyrimidine-spiro derivative and preparation method and application thereof | 山东大学 | 2021-07-20 | — | — | CN | claimed |
| CN-110177776-A | Novel modulators of 5-hydroxytryptamine receptor 7 and methods of use thereof | 英联邦高等教育系统坦普尔大学 | 2019-08-27 | — | — | CN | claimed |
| CN-105764902-B | Spiro-compound as tryptophan hydroxylase inhibitor | 卡罗斯制药公司 | 2019-02-15 | — | — | CN | claimed |
| CN-107873023-A | 3-alkyl-4-amido-bicyclo [4, 5, 0] hydroxamic acids as HDAC inhibitors | 福马治疗股份有限公司 | 2018-04-03 | — | — | CN | claimed |
| CN-105764902-A | Spirocyclic compounds as tryptophan hydroxylase inhibitors | 卡罗斯制药公司 | 2016-07-13 | — | — | CN | claimed |
| CN-102942570-A | 1-trifluoromethyl-2,8-diazospiro[4.5]decane derivative and preparation method thereof | WUHAN APPTEC NEW DRUG DEV CO LTD | 2013-02-27 | — | — | CN | claimed |
| CN-101875658-B | Preparation method of 3-carbonyl-2,8-diazepine helix[4.5]decane-8-carboxylic acid tert-butyl ester | WUXI APPTEC CO LTD | 2013-01-09 | — | — | CN | claimed |
| EP-2401262-A1 | NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2012-01-04 | — | — | EP | claimed |
| CN-101875658-A | Preparation method of 3-carbonyl-2,8-diazepine helix[4.5]decane-8-carboxylic acid tert-butyl ester | SHANGHAI HEQUAN PHARMACEUTICALS CO LTD | 2010-11-03 | — | — | CN | claimed |
| WO-2010097469-A1 | NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-02 | — | — | WO | claimed |
| EP-1171452-A2 | PYRROLIDINCARBOLYLAMINO CYCLIC DISULFIDES AS VCAM-VLA4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-16 | — | — | EP | claimed |
| WO-2000063234-A2 | PYRROLIDINCARBONYLAMINO CYCLIC DISULFIDES AS VCAM-VLA4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | claimed |
| CN-113493441-B | Novel spiro compound and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-1206414-A | N-acyl-2-substituted-4- (benzimidazolyl-or imidazopyridinyl-substituted residues) piperidines as tachykinin antagonists | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-27 | — | — | CN | disclosed |