SCHEMBL19085985 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	14/20	0.40

▸	WDR77	Q9BQA1	14/20	0.40

▸	GRIN2B	Q13224	1/20	0.40

▸	ROCK2	O75116	3/20	0.38

▸	ROCK1	Q13464	3/20	0.38

▸	METTL3	Q86U44	1/20	0.38

▸	GAA	P10253	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086036	0.93	ROCK2 (0.37)	PRMT5WDR77GRIN2BROCK2ROCK1
SCHEMBL19086003	0.92	METTL3 (0.38)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19086986	0.92	PRMT5 (0.38)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19086044	0.91	PRMT5 (0.40)	PRMT5WDR77ROCK2METTL3
SCHEMBL19085984	0.90	ROCK2 (0.42)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19086002	0.90	PRMT5 (0.38)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19086040	0.90	METTL3 (0.38)	PRMT5WDR77GRIN2BROCK2ROCK1
SCHEMBL19085992	0.89	PRMT5 (0.40)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19085997	0.89	PRMT5 (0.40)	PRMT5WDR77ROCK2ROCK1METTL3
SCHEMBL19086043	0.89	MAOB (0.36)	PRMT5WDR77ROCK2ROCK1METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed