Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085985 | 0.92 | PRMT5 (0.40) | METTL3PRMT5WDR77ROCK2ROCK1 | |
| SCHEMBL19086986 | 0.91 | PRMT5 (0.38) | METTL3PRMT5WDR77ROCK2BTK | |
| SCHEMBL19086036 | 0.90 | ROCK2 (0.37) | METTL3PRMT5WDR77ROCK2MAOB | |
| SCHEMBL19085992 | 0.90 | PRMT5 (0.40) | METTL3PRMT5WDR77ROCK2ROCK1 | |
| SCHEMBL19085997 | 0.90 | PRMT5 (0.40) | METTL3PRMT5WDR77ROCK2ROCK1 | |
| SCHEMBL19086260 | 0.89 | METTL3 (0.38) | METTL3PRMT5WDR77ROCK2BTK | |
| SCHEMBL19085979 | 0.89 | MAOB (0.41) | METTL3PRMT5WDR77ROCK2MAOB | |
| SCHEMBL19086002 | 0.88 | PRMT5 (0.38) | METTL3PRMT5WDR77ROCK2ROCK1 | |
| SCHEMBL19085984 | 0.88 | ROCK2 (0.42) | METTL3PRMT5WDR77ROCK2MAOB | |
| SCHEMBL19086039 | 0.88 | PRMT5 (0.39) | METTL3PRMT5WDR77ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |